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Longevity News 2025: Latest Longevity Research

In our January 2025 longevity newsletter, we give you a rundown of anti-ageing human trials, any longevity studies on extending lifespan of humans as well as give you something to think about for natural ageing.

Adults With ADHD May Live Shorter Lives

A new study led by UCL reveals adults diagnosed with ADHD may have reduced life expectancy.

Men with ADHD lose an average of 4.5–9 years, while women lose 6.5–11 years compared to peers without ADHD.

The research analysed data from 30,000 UK adults with ADHD and compared them to 300,000 without the condition.

Fewer than 1 in 9 UK adults with ADHD are diagnosed, leaving many without access to critical support.

Experts warn the findings may overestimate the life expectancy gap due to underdiagnosis and additional health problems, with proper ADHD treatment improving mental health and reducing risks of premature

This life expectancy research highlights an urgent need for better diagnostic and treatment services for adults with ADHD.

Further Reading: All About Nootropics: Brain Health Supplements

Maternal X Chromosome May Speed Up Brain Ageing

New longevity research shows that female mice relying only on a maternal X chromosome experience faster brain ageing and memory loss.

The maternal X accelerates ageing in the hippocampus, a brain region critical for memory and learning.

It’s been found that certain genes on the maternal X are silenced, impairing brain health, unlike the paternal X chromosome.

Using CRISPR, researchers reactivated these silenced genes, improving memory in older mice.

The study suggests the parental origin of the X chromosome may influence brain ageing and disease risk, with researchers hoping these findings could inform strategies to slow ageing and address Alzheimer’s in both sexes.

RNA Molecule Reverses Signs of Ageing in Mice

Researchers have found that injecting old mice with an RNA molecule called miR-302b can reverse some signs of ageing.

The treatment rejuvenates cells by targeting cellular senescence, a process where cells stop dividing as they age.

Mice given the treatment showed hair regrowth, better physical and mental abilities and longer lifespans.

Researchers hope the discovery could lead to anti-ageing drugs but caution that more studies are needed for human applications.

Boosting Telomerase Extends Lifespan and Helps Tissue Repair in Mice

A new study shows that overexpressing telomerase reverse transcriptase (TERT), an enzyme critical for telomere maintenance, extends mouse lifespans.

Mice with increased TERT expression lived up to 27 per cent longer and showed improved hair regrowth, wound healing and tissue repair.

Telomeres, protective DNA sequences at chromosome ends, shorten with age, but TERT overexpression prevented this process and enhanced cell regeneration.

The research highlights potential anti-ageing benefits but also notes increased cancer risk when TERT mice were exposed to harmful stimuli.

Further studies are needed to explore whether these findings could lead to safe, effective anti-ageing therapies for humans.

Further Reading: What You Need to Know About Telomeres

New Compound Boosts SIRT3 Efficiency to Support Healthy Ageing

Scientists have developed a compound that doubles the efficiency of the enzyme SIRT3 in processing NAD+, a key molecule linked to ageing and cellular health.

Unlike most drugs that obstruct enzymes, this approach improves enzyme activity, potentially boosting health and slowing ageing.

SIRT3 plays a critical role in maintaining mitochondrial health and natural variations in the gene are associated with longevity.

Using advanced algorithms, researchers screened 1.2 million compounds to identify a promising candidate, labelled 5689785, which outperformed existing NAD+ boosters in lab tests.

Although not yet tested in animals, this breakthrough could pave the way for future anti-ageing drugs targeting mitochondrial dysfunction.

Further Reading: NR or NMN to Boost NAD+ Levels

Best Time to Drink Coffee for Heart Health and Longevity

Drinking coffee in the morning may provide greater health benefits than consuming it throughout the day.

Researchers found morning coffee drinkers had a 16 per cent lower risk of death from all causes and a 31 per cent lower risk of cardiovascular disease compared to non-coffee drinkers.

All-day coffee drinkers did not experience the same benefits, likely due to caffeine's impact on circadian rhythms and sleep patterns.

Coffee contains antioxidants that protect against damage from free radicals, contributing to its positive effects on health.

It’s recommended to enjoy coffee earlier in the day to maximise its benefits while avoiding disruptions to sleep and overall wellbeing.

Probiotics May Help Preserve Muscle Strength by Restoring Gut Health

Researchers have found that gut bacteria can impact muscle strength, potentially offering a way to combat age-related muscle loss.

A study revealed that people with sarcopenia, a condition causing muscle weakness, have different gut bacteria than those without it.

When gut bacteria from people with and without sarcopenia were given to mice, the mice with non-sarcopenic bacteria had stronger muscles and better gut health.

Probiotics, specifically Lacticaseibacillus rhamnosus and Faecalibacterium prausnitzii, improved muscle size, strength and metabolism in ageing mice.

While promising, the probiotics need clinical trials to confirm their effectiveness in humans for preventing or delaying muscle loss.

Further Reading: Supplements for Digestive Health

Boosting Neuron Transport May Help Fight Alzheimer’s

Researchers have identified a protein, KIF9, as a key player in reducing harmful protein buildup in Alzheimer’s disease.

KIF9, a transporter protein that declines with age, helps neurons move cellular components critical for breaking down toxic proteins.

A study found that increasing KIF9 levels in Alzheimer’s model mice restored memory and behaviour to near-normal levels.

The mice showed improved performance in memory and anxiety tests, like maze navigation and open-space acclimation, although, while KIF9 reduced amyloid plaques and related proteins, it didn’t eliminate them entirely.

This study highlights a promising way to tackle Alzheimer’s at its root, but more research is needed to determine its potential in humans.

End Note

That’s it for January Longevity News 2025, the first edition of the year! The science of longevity is constantly evolving, hence why we publish this ageing journal each month to keep you up to date.

Whether it’s successful ageing, new longevity science supplements, how to increase healthspan or various anti-ageing news, you’ll find all the latest research on longevity here at Xandro.

If you’re interested in previous editions of the latest longevity research, you can find them here.

You can stay informed on matters surrounding your health through our weekly blogs. If you’re looking at ways to boost your health, be sure to also explore Xandro’s range of supplements.

Science-First. Trusted Longevity Solutions.