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The BEST 15 Anti-Ageing Supplements to Increase Your Healthspan

Supplements for ageing. Wouldn’t it be great to take some anti-ageing tablets and then be able to spend time with your children, grandchildren and friends for longer, to be able to travel the world and actually be able to engage in fun activities like you did when you were younger, or simply to be able to have the mental capacity and physical capabilities to continue your hobbies throughout your old age?

These are probably sentiments you’ve experienced and you may even have had a browse online for anti-ageing supplements that work. Some companies make grand claims about their supplements to get people buying them and then you get disappointed when they don’t do as they say.

So, from a supplement manufacturer, do anti-ageing supplements actually work?

Some anti-ageing supplements do work, but not all are equally effective. Scientifically proven ones, like collagen, resveratrol and CoQ10, help improve skin, energy and overall health. Just know that no pill can stop ageing completely — it can only slow down certain effects. A healthy diet, exercise and good sleep are just as important for staying younger for longer. Always check for scientific backing before buying a supplement!

So, let’s go over some scientifically proven anti-ageing supplements!

Jump there now:

• NMN (Nicotinamide Mononucleotide)

• Trans-Resveratrol

• LPC Omega-3

• Coenzyme Q10 (CoQ10)

• Curcumin

• Creatine

• Magnesium

• Ashwagandha

• Calcium AKG

• Spermidine

• Caffeine & L-Theanine

• Multivitamins

• Collagen

• Taurine

• Glutathione

15 Anti-Ageing Supplements Worth Buying

What is the most powerful anti-ageing supplement? These supplements have made our list due to the various areas they may benefit in your body. We have also provided some scientific studies to back up the claims.

1. NMN (Nicotinamide Mononucleotide) 

NMN is a molecule that helps your body produce NAD+, an essential compound that keeps your cells full of energy. As we age, NAD+ levels drop, leading to fatigue and slower metabolism. NMN can help:

• Boost energy levels by improving how your cells function.

• Support weight loss by helping your body process sugar and burn fat.

• Improve brain function by protecting brain cells and enhancing memory

• Keep your heart healthy by lowering blood pressure and cholesterol

• Promote better sleep and hormone balance

• Encourage hair growth by increasing blood flow to hair follicles.

• Extend lifespan by protecting DNA and slowing down ageing in cells.

Scientific studies show NMN, such as Xandro’s Pure NMN, is well-absorbed by the body, especially when taken in liposomal form (which helps with absorption). 

Further Reading: Safe Limits for NMN Supplements

 

2. Trans-Resveratrol

Resveratrol is a powerful antioxidant found in red wine, grapes, berries and dark chocolate. It protects your cells from ageing and helps extend your lifespan by activating special enzymes called sirtuins. Resveratrol can:

• Fight ageing by reducing inflammation and protecting cells from damage.

• Improve heart health by supporting healthy blood vessels.

• Boost brain function and possibly help prevent dementia.

• Slow down skin ageing by preventing glycation (a process that makes skin saggy and wrinkled).

Trans-Resveratrol is the most bioavailable form, meaning your body absorbs and uses it better. While resveratrol is generally safe, high doses (over 2.5g per day) may cause nausea or digestive issues.

3. LPC Omega-3 

Omega-3 fatty acids are essential for brain health, memory, and mood, but your body can’t make them on its own. They are found in fish like salmon, walnuts, and flaxseeds. Traditional omega-3 supplements aren’t easily absorbed by the brain, but LPC-bound Omega-3 (a special form) can:

• Improve brain function by keeping brain cell membranes strong.

• Support memory and focus, especially in ageing individuals.

• Reduce the risk of Alzheimer’s and dementia (especially for people with the ApoE4 gene).

• Lower inflammation, which is linked to ageing and diseases.

LPC Omega-3 is better absorbed than standard fish oil, making it a great choice for brain health, so try Xandro’s LPC Neuro supplement.

Further Reading: All About LPC Neuro

4. Coenzyme Q10 (CoQ10) 

CoQ10 is a naturally occurring antioxidant that helps your body turn food into energy. Found in organ meats, fish and spinach, it decreases with age, which can lead to fatigue and increased risk of diseases. CoQ10 can:

• Boost energy levels and improve exercise performance.

• Support heart health by reducing inflammation and protecting blood vessels.

• Slow down cognitive decline, helping with memory and brain function.

• Protect skin from wrinkles and prevent eye conditions like macular degeneration.

• Strengthen the immune system to fight off illness.

CoQ10 comes in supplements and even skincare creams to help reduce wrinkles. A typical dosage is 100–300mg per day, but it can interact with blood-thinning medications.

5. Curcumin

Curcumin is the active ingredient in turmeric, known for its anti-ageing, anti-inflammatory and brain-protecting properties. It helps:

• Reduce inflammation that causes joint pain, heart disease and diabetes.

• Support brain health by protecting nerve cells and improving memory.

• Improve gut health, which is essential for immunity and longevity.

• Boost skin health by reducing oxidative stress and promoting a youthful glow.

Since curcumin is hard to absorb, look for supplements with enhanced bioavailability (like BCM-95® Turmeric Curcumin). While safe, high doses may cause digestive issues or interact with blood-thinning medications.

Further Reading: How Curcumin Benefits the Body

6. Creatine

Creatine is a naturally occurring compound that helps your body produce energy. It’s well-known for boosting muscle strength and recovery, but it also benefits brain health. Creatine helps store and deliver energy to brain cells, improving memory, reasoning skills and focus — especially in people who don’t eat much meat. It:

• Provides a brain boost by improvingshort-term memory, intelligence and mental clarity.

• Increases muscle strength, exercise performance, muscle growth and recovery.

• Is an energy booster by giving you extra fuel for muscles and brain cells, helping with fatigue.

As one of the safest and most studied supplements, creatine supports both physical and mental vitality as we age.

7. Magnesium

Magnesium is a vital mineral needed for over 300 chemical reactions in the body. It plays a key role in energy production, muscle function, bone health and nerve communication. It also helps regulate blood sugar, blood pressure and inflammation, reducing the risk of conditions like diabetes and heart disease. It:

• Supports energy and metabolism by helping convert food into energy and helping with muscle function.

• Improves sleep and stress by calmingthe nervous system, relaxing muscles and improving sleep quality.

• Strengthens bones and your heart by reducing the risk of osteoporosis and heart disease.

Despite its importance, many people don’t get enough magnesium from food, making supplementation beneficial for long-term health. Make sure you take an absorbable form of magnesium, such as Magnesium Glycinate.

Further Reading: Is Magnesium Glycinate Safe?

8. Ashwagandha

Ashwagandha is an adaptogenic herb that helps the body handle stress, anxiety, and fatigue. It has been shown to lower cortisol (the stress hormone), improve sleep and enhance energy levels. It also supports brain function, reduces inflammation and may help slow down ageing at a cellular level. Ashwagandha may:

• Reduce stress and anxiety by lowering cortisol and improving mood and relaxation.

• Boost your energy and sleep by improving stamina while encouraging deep, restful sleep.

• Provide cell protection by supporting brain health, memory and anti-ageing mechanisms

As ashwagandha also helps with immune function, muscle recovery and even heart health, it’s a well-rounded supplement for longevity, so try Xandro’s Shoden® Ashwagandha.

9. Calcium AKG

Calcium Alpha-Ketoglutarate (Ca-AKG) is a powerful compound that helps with energy production and cellular repair. As we age, AKG levels decline, leading to reduced muscle strength, slower metabolism and weaker bones. Supplementing with Ca-AKG can counteract these effects, supporting healthy ageing. Ca-AKG may:

• Support energy and protein creation by helping cells produce energy efficiently.

• Improve bone and muscle health by reducing bone loss and muscle breakdown.

• Fights inflammation, helping protect cells from damage and supports overall longevity.

The research suggests Ca-AKG may also help with weight management, improve brain function and reduce signs of ageing at the cellular level. You can check out Xandro’s Ca-AKG supplement here.

Further Reading: Calcium AKG’s Longevity Benefits

10. Spermidine

Spermidine is a natural compound that mimics the effects of fasting by activating autophagy — the body’s process of cleaning out damaged cells and regenerating new ones. This supports metabolism, improves energy production and helps with longevity. Spermidine may help:

• Boost cell repair as ittriggers autophagy, improving cell renewal and energy levels.

• Brain and heart health as it may lower blood pressure and reduce Alzheimer’s risk.

• Improve hair, nails and your metabolism as it strengthens hair and nails while supporting weight management.

Spermidine has also been linked to improved immune function and hormone balance, making it a promising supplement for ageing well — check out Xandro’s Spermidine.

11. Caffeine & L-Theanine

Caffeine and L-theanine work together to improve brain function and focus. Caffeine is a natural stimulant that increases alertness and energy, while L-theanine, an amino acid found in tea, promotes relaxation without drowsiness. When combined, they provide a balanced boost — keeping you sharp and energised without the jittery side effects of caffeine alone. They:

• Boosts your focus and energy and improves concentration while reducing mental fatigue.

• May help with brain health by protecting against oxidative stress and age-related cognitive decline.

• Reduces stress and anxiety as L-theanine calms the nervous system, helping you stay focused and relaxed.

This combination is ideal for people looking for a natural way to enhance mental clarity and productivity while ageing.

Further Reading: All About Brain Health Supplements

12. Multivitamins

As we age, our bodies require a range of essential vitamins to support overall health. A quality multivitamin helps fill nutritional gaps, supporting immune function, energy levels and organ health. Make sure your multivitamin includes:

• B Vitamins – Support brain function, nerve health, and energy metabolism.

• Vitamin C – Boosts the immune system and helps produce collagen for skin and joints.

• Vitamin D – Strengthens bones and supports immune health.

• Vitamin E – Acts as a powerful antioxidant to protect against cell damage.

• Vitamin K2 – Helps with calcium regulation, reducing the risk of osteoporosis and heart disease.

Taking a multivitamin daily can help make sure that you get the nutrients needed for long-term health.

13. Collagen

Collagen is the most abundant protein in the body, making up skin, bones, muscles and tendons. As we age, collagen production declines, leading to wrinkles, joint pain and weaker bones. Collagen supplements help replenish lost collagen, improving skin elasticity, hydration and overall appearance. It can help:

• Give you youthful skin by reducing wrinkles, improves hydration and protects against sun damage.

• Strengthen joints and bones by supporting cartilage and bone health, as well as by reducing joint pain.

• Improve muscle mass by helping maintain strength and recovery as you age.

Hydrolysed collagen (collagen peptides) is the most effective form, easily absorbed by the body. Regular supplementation can help maintain a youthful look and strong joints.

Further Reading: Are Hair, Skin and Nail Supplements Worth It?

14. Taurine

Taurine is an amino acid essential for brain, muscle and heart function. Research suggests it may slow ageing and promote longevity. A study of over 12,000 older adults found that those with higher taurine levels had lower rates of obesity, inflammation, high blood pressure and diabetes. Taurine helps:

• Heart and metabolic health by helping regulate blood sugar, blood pressure and cholesterol.

• Improve energy levels and muscle function by improving endurance, strength and recovery.

• Improve brain function as it reduces anxiety and supports mental well-being.

• Strengthen the immune system as it helps fight inflammation and supports healthy ageing.

Taurine is naturally found in meat, fish and dairy, but supplementation may benefit older adults looking to maintain vitality.

15. Glutathione

Glutathione is one of the body’s most powerful antioxidants, protecting cells from damage, detoxifying the liver and supporting immune function. It also plays a key role in regenerating other antioxidants, like vitamins C and E, making them more effective. Glutathione:

• Fights oxidative stress as it protects against cell damage and slows the ageing process.

• Supports liver health by helping detoxify harmful substances and improving liver function.

• Improves immunity as it reduces inflammation and supports the body’s natural defences.

As we age, glutathione levels decline, making supplementation a great way to enhance overall health and longevity.

Further Reading: Top Glutathione Alternatives

What is the Best Anti-Ageing Supplement?

This will depend on your specific health concerns and which one your doctor recommends or finds won’t interfere with any medications you’re taking or your medical history. Make sure the ingredients listed within the supplement have scientific studies backing the claims, such as collagen for your skin, resveratrol for your cells and CoQ10 for energy, and that there are no added fillers. 

Since the supplement industry is not regulated, make sure the company puts their supplements through third-party testing to ensure the quality and purity of the product and make sure you’re purchasing from a reputable brand with great customer reviews. 

End Note

Other top anti-ageing supplements may also improve your longevity, including alpha lipoic acid (ALA), phosphatidylcholine and sialic acid, so speak with your doctor to see which would suit you best.

If you’re looking for a single supplement to take which provides you with your longevity needs, we would recommend taking a daily multivitamin and possibly also considering an all-in-one anti-ageing supplement likeProtocol X, a longevity multivitamin that contains over 20 science-backed ingredients for your brain health, body systems and potentially improve your healthspan. 

As always, have a chat with your doctor about your health concerns and whether taking any of the supplements above will be right for you and your medical history.