Dr David Sinclair’s Supplement Stack to Reverse Aging

Dr David Sinclair’s Supplement Stack to Reverse Aging

25th May 2024

Top David Sinclair Supplements for Longevity and Health

If you’re into the longevity scene, we’re sure you’ve heard about Dr. David Sinclair. David Sinclair’s age is nearly 55, but he certainly doesn’t look it.

Dr. Sinclair is renowned for his research into aging and longevity and believes it’s possible to live up to 150 years old — maybe even longer! Using himself as his guinea pig, his biological age has been found to be much younger than his chronological age, but have you ever wondered what he does to achieve this?

This article will cover a little bit about Dr. Sinclair as well as go over his supplement and drug stack that he’s spoken about in interviews and books.

Jump there now:

Who Is David Sinclair?

Doctor David Sinclair is a professor in the Department of Genetics at Harvard Medical School. He’s well known for his work on understanding how humans age and how to slow its effects. His early research focused on sirtuins, protein-modifying enzymes that respond to changing NAD+ levels and calory restriction, but his interests also span epigenetics, energy metabolism, learning and memory, neurodegeneration, mitochondria and cancer.

If interested, you can find Dr. David Sinclair’s aging research in books, documentaries 60 minutes episodes and other media, and he is the inventor of over 50 patents and has received more than 35 awards and honours for his work.

But how does David Sinclair reverse aging and what vitamins does David Sinclair take?

Dr. David Sinclair’s Supplement Stack

Nicotinamide mononucleotide (NMN)

Dosage: 1g per day, in the morning

Prescription: No

Why take NMN Supplements?

  • Boosts the production of NAD+
  • Improve energy levels
  • Improve metabolism
  • Supports hormone function

David Sinclair NMN dosage is quite high, with research showing benefits from 250mg each day. Here at Xandro, we’ve spoken a lot on the benefits of NMN. If you’re interested in grabbing yourself a bottle, why not try Xandro Lab’s Pure NMN Capsules and Pure NMN Powder?

Further Reading: Longevity benefits of NMN


Dosage: 1g per day, in the morning

Prescription: No

Why take Resveratrol?

  • Activates sirtuins, anti-aging genes that protect our DNA
  • Promotes mitochondrial function
  • Supports inflammatory response
  • Improve insulin response

There are so many benefits from taking resveratrol, commonly found as trans-resveratrol. It’s a great supplement to take alongside NMN as they complement each other. Learn about the research behind Xandro Lab’s Trans-Resveratrol here, or grab your hands on a bottle today.

Further Reading: Weight Loss Benefits of Resveratrol and the Brain Benefits of Resveratrol

TMG (trimethyl glycine or betaine)

Dosage: 500mg to 1,000mg per day

Prescription: No

Why take TMG?

  • Supports DNA methylation, which links with epigenetic age
  • Our methyl pools deplete as we age, linking to age-related diseases


Dosage: 800mg, in the evening

Prescription: Yes

Why take Metformin?

  • May increase lifespan in animal studies
  • Improves insulin sensitivity and regulates blood glucose levels
  • May benefit cardiovascular health
  • Don’t take on days when you workout as it may reduce the benefits of exercise

Vitamin D3

Dosage: Ideally 4,000 to 5,000IU per day

Prescription: No

Why take Vitamin D3?

  • Vitamin D deficiency has been linked to type 2 diabetes, heart disease, autoimmune disorders and Alzheimer’s disease
  • Activates genes that are important for our health

Further Reading: Ultimate Guide to Longevity Supplements

Vitamin K2

Dosage: Ideally 180 to 360μg per day

Prescription: No

Why take Vitamin K2?

  • Improves skin quality
  • Strengthens bones
  • Improves mitochondrial function
  • Improves vascular health


Dosage: Unknown

Prescription: Yes

Why take Statin?

  • Prevents cardiovascular disease by lowering LDL cholesterol
  • Despite this, taking statin increases the risk of developing myopathy

Low-Dose Aspirin

Dosage: 83mg per day

Prescription: No

Why take Low-Dose Aspirin?

  • Used to lower the risk of heart attack, inflammation and cancer
  • Speak to your doctor before taking as it may damage your stomach

Alpha Lipoic Acid (ALA)

Dosage: Unknown

Prescription: No

Why take ALA?

  • May activate certain cell pathways used for energy production and metabolism
  • It’s an antioxidant
  • Can reduce LDL and total cholesterol levels
  • Research is mixed, though

Further Reading: Supplements for Diabetics

Coenzyme Q10 (CoQ10)

Dosage: Unknown

Prescription: No

Why take CoQ10?

  • It’s an antioxidant
  • Directly influences genes used in aging and inflammation
  • Despite this, don’t take too high a dosage

Xandro’s POM-Q10 is a unique blend of amla, pomegranate and CoQ10, the first on the market, that work together to help the visible signs of aging, combat oxidative stress and enhance cardiovascular protection. Grab yours today!

Further Reading: The Benefits of Pomegranate Supplements


Dosage: 1mg per day, in the morning

Prescription: No

Why take Spermidine?

  • Induces autophagy, used to adapt to stress and cell damage
  • Increases lifespan in animal studies and delays aging in humans

At Xandro, we know all about the benefits of spermidine, so much so that we have a page dedicated to its research! We’ve also written all about its weight loss and longevity benefits, so if you would like to see if it can benefit you, consider grabbing yourself a bottle!

Further Reading: Why You Should Be Taking Spermidine

Quercetin and Fisetin

Dosage: 500mg each, once per day, in the morning

Prescription: No

Further Reading: The Longevity Benefits of Fisetin

Why take Quercetin and Fisetin?

  • Quercetin and fisetin can remove senescent (old cells that cause inflammation and accelerate degeneration of healthy cells)

Further Reading: Does Quercetin Help Remove Grey Hairs?

David Sinclair Diet

Ever wondered what food David Sinclair eats to help his longevity journey? Let’s go over what he has shared about his diet.

  • Yoghurt: David Sinclair adds white resveratrol powder, olive oil, probiotics and NMN to a little bit of yoghurt before breakfast to get his polyphenols in each day.
  • Water: He starts his day wat hot water and lemon.
  • Green Matcha Tea: This is David Sinclair’s caffeine source, which is full of polyphenols like ECGC catechins.
  • Intermittent Fasting: David Sinclair incorporates 16:8 intermittent fasting into his daily routine. This means getting all his nutrition and calories in a certain window and then not eating a large meal for about 16 to 18 hours. He has mentioned following a monthly five-day calorie restriction of only 1100 calories per day, predominantly eating plant-based, low-carb, low-protein and high healthy fat foods.
  • Snacking: If peckish, David Sinclair will eat a little bit of 80 per cent chocolate or some nuts.
  • Skipping Lunch: Most days he skips lunch, although maybe once or twice a week he eats a small salad.
  • Dinner: He eats minimal sugar and starchy foods, instead eating light and healthy plant-based meals. Often, this includes a plant-based, nut-based dinner with rice, almonds, couscous or crushed cassava.

What Else Does David Sinclair Do for Longevity?

Longevity is not only about supplements and diet, which Dr. Sinclair also mentions. Here are some other factors that go into his longevity routine:

  • Sleep: Sleeps at least six hours each night, aiming for seven to eight, as well as sleeps in a bed that adjusts his body temperature.
  • Morning: Rinses his mouth with coconut oil each morning and then brushes his teeth with non-toxic toothpaste.
  • Work: Works at a standing desk and does his best to avoid sitting.
  • Diet: Avoids alcohol and dairy.
  • Exercise: Tries to do a weight-lifting routine three times a week as well as a daily run (or walk if he doesn’t have the energy). He practices cold therapy after exercise.
  • Stress: He meditates to reduce his stress.
  • Tracking: David Sinclair frequently has blood tests and tracks his glucose levels, steps and sleep so he can understand what’s happening in his body.

End Note

It’s important to note that Dr. Sinclair himself said that you don’t have to be so strict with your longevity practices, just as long as you’re consistent and try your best given your individual circumstances.

Now that you know the David Sinclair supplements list, this can help you to conduct further research to determine whether any of these are right for you, making sure to speak with your doctor before you do as what’s healthy and needed for someone else might not be healthy for you.

It’s important to stay informed about the supplements you’re taking as well as just to keep yourself educated about your body, so be sure to check out the Xandro blog to continue learning!

Decided you want to grab one of Xandro Lab’s supplements for longevity and healthy aging? Be sure to first read our ultimate guide to starting supplements before you do so that you’re informed about how to take each supplement.

Interested in the research that David Sinclair lab produces? Check out some of his research projects here.